What would yall say is the most annoying debuff?

For me, it HAS to be Berserk. One of my main monsters is Shining Kuneko, and honest to goodness- when Breathing Technique doesn't proc, it is ANNOYING AS HELL to be unable to use non attacking moves, AND for it to cancel things like Berserker and Neutralise (the latter was meant to get rid of the Berserk, mind you!, but it apparently doesn't despite Berserk clearly being a DEBUFF)