We got out to Canada in 2023 - what I'd do differently
We got our family out of Florida in 2023 and moved to the Maritimes in Canada. 2 small kids and 2 dogs. Seems like the timing was lucky, in hindsight! But here is what we would do differently.
Start earlier! We thought about it for years but never did more than read some things online. If you are serious, just start earnestly. Pay for an hour with an immigration lawyer to ask a million questions about every possible pathway. Research if your job credentials transfer. Job hunt. Whatever, just do something.
Don't worry about what family/friends think. This kept us from getting serious for awhile. You know yourself/your nuclear family better than anyone else. Deep down, you know what is right for you. Some family/friends may be supportive, some will definitely question you, some might get hostile/think you're crazy (especially if you have kids and/or great jobs in the U.S.). Don't let them get to you! Some of what they will say/do will be out of jealousy, fear for you, fear of losing you, etc. But at the end of the day, you have to do what's best for you/your family, even if it's moving them far away from where you are.
Save money earlier! Obviously moving out of the country is expensive, and saving a lot of money isn't feasible for everyone, but if you're really serious about moving, start putting as much as you can aside for the move every month, no matter how little it is. The move will cost more than you think, 100%. So better to prepare for it now than scramble to deal with it later.
Consider un-sexy parts of your destination country! Maybe the biggest one. Well, we did do this one, but not at first. Everyone going to Canada wants to move to Vancouver or Toronto or Montreal. And I get why. But, at least for Canada, the immigration programs and jobs for immigrants are SO much more plentiful outside of the big cities/provinces, that if you are serious about getting out, you really should expand your options and make yourself open to anywhere. My wife is a doctor and I really, really wanted to be in British Columbia, but they make it really hard for doctors to move there, and New Brunswick (where we ended up) makes it super, duper easy for doctors to move there, and provided so much support for doctors moving there, that it was a no brainer for us. If we would have only been looking in Vancouver or Toronto, we likely would've never made the move, cause we would've never found a job that qualified or a way to get a medical license or a million other things that we were able to do easily here.
There are probably more but I don't want to write a book (yet) - happy to answer any questions though!